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Synapse
May 2, 20263 citations

Self-Cascading Copper-Based Nanoassemblies Trigger Bacterial Cuproptosis-Like Death and Promote Wound Healing for Diabetic Drug-Resistant Bacterial Infections.

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TFTianji FengWFWenjie FanYZYin Zhang

Key Points

  • The aim is to evaluate the efficacy of copper-based nanoassemblies in treating drug-resistant bacterial infections and promoting wound healing.
  • Used MRSA-infected diabetic foot ulcer and diabetic MRSA keratitis models to validate efficacy.
  • Assessed multifunctional efficacy including bacterial eradication and inflammatory reduction.
  • Demonstrated significant bacterial eradication in both models with copper nanoassemblies.
  • Achieved notable tissue regeneration and inflammation mitigation post-treatment.

Abstract

facilitates tissue regeneration. MRSA-infected diabetic foot ulcers and diabetic MRSA keratitis models validated DC/Cu's multifunctional efficacy in bacterial eradication, inflammatory mitigation, and tissue regeneration. Collectively, these multifunctional nanoassemblies demonstrate a promising and effective approach for precision therapeutic intervention against MDR pathogen-aggravated diabetic complications.

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Cite This Study

Feng et al. (2026) studied this question.

synapsesocial.com/papers/69f5941871405d493affee88https://doi.org/10.1021/acsnano.5c21619
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