Co-occurrence of the tigecycline resistance gene cluster tmexCD3-toprJ1 and verona integron-encoded metallo-β-lactamase (VIM) in a human-derived Pseudomonas sediminis isolate.

Heng Shen; Aoxiao Chen; Chang Cai; Rong Zhang; Hongwei Zhou; Dazhi Jin

doi:10.1128/spectrum.03491-25

April 30, 2026

Co-occurrence of the tigecycline resistance gene cluster tmexCD3-toprJ1 and verona integron-encoded metallo-β-lactamase (VIM) in a human-derived Pseudomonas sediminis isolate.

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Key Points

To investigate the co-occurrence of the tigecycline resistance gene cluster tmexCD3-toprJ1 and the VIM gene in a human-derived isolate.
Genomic analysis of a Pseudomonas sediminis isolate from a child's intestinal tract.
Assessment of genetic environment surrounding resistance genes.
The tigecycline resistance gene cluster tmexCD3-toprJ1 was found alongside VIM in the isolate.
The genes are present in various bacterial hosts, indicating a potential for broader dissemination of resistance.
The complex genetic environment raises concerns about the spread of antimicrobial resistance.

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Implication

Genomic analysis reveals co-occurrence of resistance genes in Pseudomonas sediminis, indicating potential for antimicrobial resistance spread.

Abstract

from a child's intestinal tract. Genomic analysis revealed that the gene cluster is present in different hosts and associated with a complex genetic environment. IMPORTANCE: in a complex gene environment. We highlight that these genes have the potential to disseminate across bacterial hosts and may represent a potential reservoir for antimicrobial resistance dissemination.

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Shen et al. (2026) studied this question.

synapsesocial.com/papers/69f5941871405d493affef82 https://doi.org/10.1128/spectrum.03491-25

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Co-occurrence of the tigecycline resistance gene cluster tmexCD3-toprJ1 and verona integron-encoded metallo-β-lactamase (VIM) in a human-derived Pseudomonas sediminis isolate.

Key Points

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Implication

Abstract

Discussion

Cite This Study

Co-occurrence of the tigecycline resistance gene cluster tmexCD3-toprJ1 and verona integron-encoded metallo-β-lactamase (VIM) in a human-derived Pseudomonas sediminis isolate.

Key Points

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Abstract

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