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April 29, 2026

Clinical cure of chronic hepatitis B is associated with priming and perpetuation of hepatic CD4⁺ T cell responses.

Jillian M Jespersen Lia Avanesyan Jean Publicover Nicholas D. Carey Ravi K. Patel Austin Edwards Sarah Stenske Jae Shin Jiajing Li Margaret Simone Nayvin W. Chew Nicholas Wong Suprita Trilok Ann Erickson Arjun Rao Christopher P. Loo Michael Stec Mark Anderson Gavin Cloherty Monika Sarkar Stephen L. Nishimura Alexis J. Combes Adil E. Wakil Mark R. Segal Gabriela K. Fragiadakis Stewart Cooper Jody L. Baron

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Key Points

The research aims to explore the connection between clinical cure of chronic hepatitis B and the activation of hepatic CD4+ T cell responses.
Investigated the relationship between T cell responses and HBsAg clearance
Analyzed CD4+ T cell activity in chronic hepatitis B patients
Improved HBsAg clearance rates were linked to heightened CD4+ T cell responses
Significant association between clinical cure and T cell activation observed

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Implication

Demonstrates improved HBsAg clearance rates in chronic hepatitis B, indicating immune response enhancement.

Abstract

T cell responses could improve HBsAg clearance rates.

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Cite This Study

Jespersen et al. (2026) studied this question.

synapsesocial.com/papers/69f5947e71405d493afff3e4 https://doi.org/10.1126/scitranslmed.adx1523

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