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May 2, 20260 citations

Effect of a Combined Antidepressant Drug Flupentixol-Melitracen on Glucose Level and Expression of Insulin-Like Peptide Genes DILP5 and DILP6 in Drosophila melanogaster.

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ABAzizul Islam BarkatKAKhandaker Asif AhmedSASumaiya Akter

Key Points

  • The aim is to explore the impact of flupentixol-melitracen on glucose levels and the expression of insulin-like peptide genes in Drosophila melanogaster.
  • Drosophila melanogaster were treated with flupentixol-melitracen.
  • Expression of DILP5 and DILP6 genes was measured post-treatment.
  • Statistical analysis of gene expression differences was conducted.
  • DILP5 gene expression was slightly higher in the antidepressant-treated group but not statistically significant.
  • No significant change in DILP6 gene expression was observed.
  • Further investigations are needed to confirm the relationship between antidepressants and insulin signaling.

Abstract

method. The DILP5 gene was expressed slightly higher in the antidepressant-treated group, though the expressions of the DILP genes appeared statistically insignificant. The current study suggests that anxiolytics and antidepressant drugs might be associated with the insulin signaling pathway, which is crucial for growth, glucose regulation, and other fundamental metabolic processes. Further study is required to determine the expression pattern of all DILP and other genes that might affect glucose homeostasis.

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Cite This Study

Barkat et al. (2026) studied this question.

synapsesocial.com/papers/69f5947e71405d493afff460https://doi.org/10.1155/bmri/6698526
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