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May 2, 20260 citations

Temporal Interference Stimulation Affects Motor Circuit Connectivity in Parkinson's Disease

Temporal Interference Stimulation Modulates Resting State Functional Connectivity of Motor Circuit in Parkinson's Disease.

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Authors

YXYongxin XuCYChenhao YangYDYichao Du

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Overview

Randomized trial examines effects of temporal interference stimulation on motor circuit connectivity in Parkinson's disease, suggesting new neuromodulation strategies.

Key Points

  • This study aims to understand how transcranial temporal interference stimulation affects functional connectivity in the motor circuit in Parkinson's disease.
  • Randomized, double-blind, crossover study with 23 participants having mild-to-moderate Parkinson's disease.
  • Participants underwent 20-minute sessions of 130 Hz temporal interference targeting the subthalamic nucleus and active sham stimulation.
  • Functional connectivity was assessed through resting-state fMRI and clinical scales before and after stimulation.
  • 130 Hz STN-TIs significantly decreased functional connectivity between the targeted side of STN and putamen (P = 0.004-0.046).
  • Connectivity between the targeted side of STN and caudate was also decreased (P < 0.001).
  • An increase in functional connectivity was noted between the targeted side of STN and M1 (P = 0.002-0.004).

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69f5947e71405d493afff475https://doi.org/10.1002/mds.70321
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