Anti-Thyroglobulin Antibodies as a Surrogate Tumor Marker for the Follow-Up of the Differentiated Thyroid Carcinoma: Clinical Implications and Pitfalls.

Key Points

• This research aims to evaluate the role of antithyroglobulin antibodies as tumor markers in the follow-up of differentiated thyroid carcinoma.
• Analyzed the effectiveness of antithyroglobulin antibody positivity in detecting recurrence.
• Emphasized the use of neck ultrasonography for imaging-based surveillance.
• Integrated trends of antithyroglobulin antibody levels with imaging results.
• Antithyroglobulin antibody positivity did not serve as an early biomarker of recurrence.
• Neck ultrasonography remained essential for effective follow-up in positive antibody cases.
• Antithyroglobulin antibodies acted as both interferents and surrogate markers in monitoring patients.