Active brown adipose tissue was associated with reduced aortic inflammation and a less atherogenic circulating profile, including lower proatherogenic factors and IL-6, compared to BAT negative.
Observational
Is active brown adipose tissue associated with reduced arterial inflammation and a less atherogenic circulating profile in individuals with obesity?
Active brown adipose tissue in humans with obesity is associated with reduced arterial inflammation and a potentially atheroprotective circulating profile.
BACKGROUND: Increasing evidence from preclinical models has linked the actions of brown adipose tissue (BAT) with protection against atherosclerosis and cardiovascular disease, in part due to its salutary effects on systemic lipid composition. However, human data on the role of BAT in atherosclerosis are scarce. METHODS: F-fluorodeoxyglucose positron emission tomography combined with computed tomography in combination with systemic lipidomics and proteomics analyses. RESULTS: , and cold-induced thermogenesis correlated negatively with aortic inflammation, suggesting an atheroprotective role of BAT. Using unbiased lipidomics and proteomics analyses in plasma, we found that anti-inflammatory and potentially antiatherogenic circulating factors, such as cytochrome P450 oxylipin products and the serpin family member SERPINB12, were increased in BAT positive, whereas proatherogenic and prothrombotic factors, including acute phase protein ORM2 (orosomucoid 2), APOD (apolipoprotein D), FGA (fibrinogen A), and FGB (fibrinogen B), were significantly lower in individuals with active BAT. Likewise, the circulating concentrations of inflammatory markers, such as IL-6 (interleukin-6), were reduced in BAT positive versus BAT negative. CONCLUSIONS: Together, these data link human BAT function with protection against arterial inflammation and a potentially antiatherogenic and anti-inflammatory circulating profile. REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifiers: NCT02381483 and NCT03168009.
Kulterer et al. (Thu,) conducted a observational in Obesity. Active Brown Adipose Tissue (BAT positive) vs. BAT negative was evaluated on Aortic inflammation and circulating lipid/protein profile. Active brown adipose tissue was associated with reduced aortic inflammation and a less atherogenic circulating profile, including lower proatherogenic factors and IL-6, compared to BAT negative.