In vitro findings show triclabendazole disrupts mitochondrial function in helminths and mammalian cells, implying safety risks.
, while other benzimidazoles do not. Similar effects were observed in mitochondria from additional helminths (trematodes, nematodes) and mammalian cells. These findings indicate a shared mode of action and highlight potential safety risks associated with long-term triclabendazole treatment in mammals.
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Kämpfer et al. (2026) studied this question.
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