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Synapse
May 2, 20261 citations

Triclabendazole disrupts mitochondrial electron transport in vitro.

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TKTobias KämpferUniversity of BernMAMaría Eugenia AncarolaUniversity of BernPZPascal ZumsteinUniversity of Bern

Key Points

  • This research investigates the effects of triclabendazole on mitochondrial electron transport in different organisms.
  • In vitro analysis of mitochondrial function in various helminths and mammalian cells.
  • Comparison with other benzimidazoles to assess the specificity of the effects.
  • Triclabendazole significantly disrupts mitochondrial electron transport in tested helminths and mammalian cells.
  • No similar disruption was observed with other benzimidazoles, indicating a unique action of triclabendazole.

Abstract

, while other benzimidazoles do not. Similar effects were observed in mitochondria from additional helminths (trematodes, nematodes) and mammalian cells. These findings indicate a shared mode of action and highlight potential safety risks associated with long-term triclabendazole treatment in mammals.

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Cite This Study

Kämpfer et al. (2026) studied this question.

synapsesocial.com/papers/69f5947e71405d493afff4f3https://doi.org/10.1128/aac.01756-25
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