Genetic risk score as a predictor of gestational diabetes in Central European Caucasians.

. The same scores derived from the ARAP1, NOTCH2, and MTNR1B genes discriminate between the GDM and T2DM groups (P < 0.0001). Identification of statistically significant association of the population-specific wGRS with GDM susceptibility supports its potential clinical utility for the risk stratification of pregnant women (beyond established non-genetic risk factors). Yet, the actual health care adoption of GRS in the near future is unlikely, since additional validation, regulatory and administrative steps, thorough economic analyses, ethical discussion, etc. are certainly required.