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May 2, 2026

Pre-transplant hepatocellular carcinoma is associated with increased risk of post-transplant non-HCC cancer in liver transplant recipients.

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Authors

ASA A SaqahWestern UniversityPAPedro AcuñaPontificia Universidad Católica de ChileFIFrancisco Idalsoaga

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Implication

Retrospective cohort study investigates cancer types and frequency in liver transplant recipients, indicating enhanced surveillance needs.

Key Points

  • This study aims to understand the prevalence and types of cancers that occur after liver transplantation, specifically in patients with pre-transplant hepatocellular carcinoma (HCC).
  • Conducted a retrospective cohort study from 2007-2018 in Ontario with 60-month follow-up.
  • Assessed de novo and recurrent malignancies using institutional cancer registries.
  • Evaluated time-to-event associations using Cox proportional hazards models.
  • Post-transplant malignancy was common, with significant variation based on pre-transplant liver disease.
  • Patients with pre-transplant HCC had a notably higher incidence of post-transplant cancers (p=0.003).
  • Findings support the need for enhanced dermatologic surveillance and tailored screening for liver transplant recipients.

Cite This Study

Saqah et al. (2026) studied this question.

synapsesocial.com/papers/69f594ca71405d493afffa0ahttps://doi.org/10.1080/00365521.2026.2663329
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