What question did this study set out to answer?

The aim is to assess the toxic effects of methyl parathion on enzyme activities in Heteropneustes fossilis.

May 2, 2026Open Access

Toxic Effect of Organophosphorus Insecticide – Methyl Parathion on Alt, Ast& LDH Activity in Fresh Water Fish Heteropneustes Fossilis

Key Points

The aim is to assess the toxic effects of methyl parathion on enzyme activities in Heteropneustes fossilis.
Fish were exposed to sublethal concentrations of methyl parathion (0.25, 0.5, 1.0 mg L⁻¹) for 15, 30, and 45 days.
Activities of AST, ALT, and LDH were measured to evaluate biochemical responses.
AST activity increased with exposure concentration and time, indicating tissue damage.
ALT showed a similar pattern of increase, suggesting muscular impairment.
LDH activity elevation indicates increased cellular necrosis and physiological stress.

Abstract

The freshwater fish Heteropneustes fossilis was exposed to sublethal concentrations (0.25, 0.5, and 1.0 mg L⁻¹) of the organophosphorus insecticide methyl parathion (MP) for exposure periods of 15, 30, and 45 days. The activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) showed a concentration-dependent increase, indicating tissue damage and muscular impairment resulting from MP exposure. Similarly, elevated LDH activity suggests enhanced lysosomal mobilization and cellular necrosis. These biochemical alterations clearly demonstrate that methyl parathion exerts toxic effects even at sublethal concentrations, disrupting intermediary metabolism and indicating significant physiological stress in Hteropneustes fossilis.

AI에게 질문

Bookmark

View Full Paper