Demonstrates enhanced fumagillin derivative production in human cells, suggesting new drug delivery methods.
Intracellular biosynthesis of natural products in human cells represents a promising strategy for functional drug delivery. Here we engineered production of fumagillin metabolites in human cells expressing fungal cytochrome P450 Fma-P450. In endothelial-derived EA.hy926 cells, metabolic flux optimization enhanced metabolite production and enabled detection of cytotoxic activity.
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Shinya Matsuda (2026) studied this question.
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