Visible-Light-Induced FeCl3-Promoted Dehydroxypropylative Selenylation of Acyclic Alcohols.

Key Points

• The objective is to develop a new method for synthesizing unsymmetrical monoselenides from acyclic alcohols using diselenides.
• Developed a protocol for dehydroxypropylative selenylation of tertiary acyclic alcohols with diselenides.
• Investigated the reaction's substrate scope across multiple diselenides and alcohols.
• Conducted mechanistic studies to support the pathway initiated by ligand-to-metal charge transfer upon light irradiation.
• The protocol enables C-C bond cleavage and C-Se bond formation without needing an additional photocatalyst.
• The reaction shows a broad substrate scope and is suitable for gram-scale synthesis.
• Mechanistic studies confirm the reaction follows a radical pathway.