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Observational study reports genetic features of B-cell and plasma cell disorders linked to T follicular helper cells, suggesting clinical insights.
mutation was detected in 3 cases, most likely representing contamination by minor nTFHL clones. In conclusion, TFHL-associated B/PCP are a heterogeneous group of lymphoproliferative and plasma cell disorders, displaying recurrent histological patterns and frequent clonal hematopoiesis-associated mutations. Further studies on larger cohorts of patients are warranted to elucidate their biological and clinical implications.
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Pizzi et al. (2026) studied this question.
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