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April 30, 2026

Regioselective Oxidative Coupling of Monohalogenated Phenols.

Ratnadeep Bera Raja Kapanaiah Doron Pappo

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Key Points

The aim is to establish a scalable method for the regioselective oxidative coupling of monohalogenated phenols.
Conducted oxidative coupling reactions in 1,1,1,3,3,3-hexafluoropropan-2-ol under air atmosphere at elevated temperatures.
Utilized -tetramethylethylenediamine as a catalyst for coupling reactions.
Successfully synthesized 3,3'-, 4,4'-, and 5,5'-dihalo-2,2'-biphenols as products.
Demonstrated that the protocol is scalable and provides access to valuable synthetic intermediates.

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Implication

Explores the synthesis of complex biphenyl architectures from monohalogenated phenols, suggesting a new methodology for chemical intermediates.

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Cite This Study

Bera et al. (2026) studied this question.

synapsesocial.com/papers/69f5955971405d493a00035d https://doi.org/10.1021/acs.orglett.5c05436

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