Chemoenzymatic Synthesis with Plant Oxidases and Metabolic Engineering Enable Rapid Access to Rare Gibberellins.

, we also accessed 15β-hydroxylated gibberellins in a single step by metabolic engineering. In summary, our work enables the flexible and sustainable synthesis of rare gibberellins and other highly oxidized diterpenoids. More importantly, our work demonstrates how plant oxidases can be used in chemoenzymatic synthesis and total biosynthesis campaigns, which will help to better utilize the catalytic potential of these previously neglected enzymes in the future.