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OBJECTIVE: Post-traumatic stress disorder (PTSD) is one of the most prevalent psychological disorders. Methods to alleviate its symptoms range from 'talking therapies' to pharmaceutical interventions. Our objective was to carry out a systematic review of the effectiveness of sertraline, an SSRI, as a treatment for PTSD. METHOD: Databases were searched to identify relevant research on sertraline as a treatment for PTSD. RESULTS: Five randomised control trials were identified, along with seven open trials and case series studies. CONCLUSIONS: The review and meta-analysis supported the use of sertraline for PTSD though further research on sub-group differences (eg. gender) is required.
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Mooney et al. (2004) studied this question.
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