Why the study?
Sex differences in left ventricular remodeling and outcomes are established in severe aortic stenosis, but have not been evaluated in moderate aortic stenosis.
Does male sex worsen all-cause mortality in patients with medically treated moderate aortic stenosis compared to female sex?
Does male sex worsen all-cause mortality in patients with medically treated moderate aortic stenosis compared to female sex?
In patients with medically treated moderate aortic stenosis, male sex is associated with worse outcomes and distinct LV remodeling patterns compared to females.
Answers are grounded in this paper and cite their sources.
Male sex may flag higher-risk moderate AS for surveillance; hypothesis-generating for sex-specific thresholds, pending prospective validation.
Background: Recent data showed poor long-term survival in patients with moderate AS. Although sex differences in left ventricular (LV) remodeling and outcome are well described in severe AS, it has not been evaluated in moderate AS. Methods: In this retrospective, multicenter study, patients with a first diagnosis of moderate AS diagnosed between 2001 and 2019 were identified. Clinical and echocardiographic parameters were recorded at baseline and compared between men and women. Patients were followed up for the primary endpoint of all-cause mortality with censoring at the time of aortic valve replacement. Conclusions: LV remodeling patterns are different between men and women having moderate AS. Male sex is associated with worse outcomes in patients with medically treated moderate AS. Further studies investigating the management of moderate AS in a sex-specific manner are needed.
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Stassen et al. (2022) studied this question.
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