February 1, 1973CirculationOpen Access

Electrical Stability of Acutely Ischemic Myocardium

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Why the study?

Does increasing heart rate during acute myocardial ischemia diminish electrical stability of the ventricle in an animal model?

Population

Experimental animal model (dogs) with acute myocardial ischemia

Comparison

Increasing heart rate with or without cervical… vs Lower heart rates (50-60 beats/min)

Design

Preclinical

Authors

KKKenneth M. KentBoston University ESEldon R. SmithUniversity of Calgary DRDavid R. RedwoodUnited States Department of Health and Human Services

Discussion

Member takes

Implication

Tachycardia during ischemia may reduce ventricular electrical stability; hypothesis-generating for rate targets in acute MI.

Structured PICO

Does increasing heart rate during acute myocardial ischemia diminish electrical stability of the ventricle in an animal model?

Population

Experimental animal model (dogs) with acute myocardial ischemia

Intervention

Increasing heart rate (from 50-60 up to 180 beats/min) with or without cervical vagal stimulation

Comparator

Lower heart rates (50-60 beats/min)

Outcome

Electrical stability of the ventricle, assessed by disparity of refractory periods (RP) and ventricular fibrillation threshold (VFT)surrogate

Increasing heart rate during acute myocardial ischemia decreases ventricular electrical stability by increasing ischemia and through direct vagal electrophysiologic effects, challenging the hypothesis that higher heart rates are protective.

Cite This Study

Kent et al. (1973) studied this question.

synapsesocial.com/papers/69f69177e405cc4465bc2b9e https://doi.org/10.1161/01.cir.47.2.291

View Full Paper

Ask AI

Bookmark

Electrical Stability of Acutely Ischemic Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Electrical Stability of Acutely Ischemic Myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider