Why the study?
Does intramyocardial BDNF increase inflammation and myocardial injury in aging rat hearts?
Population
3- and 18-month-old mice, and 4- and 24-month-old rats
Comparison
Intramyocardial injections of brain-derived… vs PBS control
Design
Preclinical
Authors
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BDNF should not inform clinical decisions in older adults; leaves open age-specific BDNF-TrkB effects on MI injury.
Does intramyocardial BDNF increase inflammation and myocardial injury in aging rat hearts?
Age-associated changes in BDNF-Trk B pathways may predispose the aging heart to increased injury after acute myocardial infarction.
Cai et al. (2005) studied this question.
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