What is the clinical evidence from this study?

Study design: Cohort. Population: Obstructive sleep apnea and percutaneous coronary intervention (n=371). Intervention: Treatment for obstructive sleep apnea vs. Untreated obstructive sleep apnea. Primary outcome: cardiac death (p=0.027).

What question did this study set out to answer?

To determine whether treatment for obstructive sleep apnea improves survival and clinical outcomes in patients undergoing percutaneous coronary intervention.

May 3, 2026Journal of the American College of Cardiology

Treatment of Obstructive Sleep Apnea Is Associated With Decreased Cardiac Death After Percutaneous Coronary Intervention

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Key result

OSA treatment post-PCI is linked to ~70% lower 5-year cardiac death risk vs no treatment.

P=0.027
n=371

Why the study?

It is not known whether treatment of obstructive sleep apnea in patients who have had PCI results in better cardiovascular outcomes.

Does treatment for obstructive sleep apnea reduce cardiac death and adverse events in patients who have undergone percutaneous coronary intervention?

Population

371 patients with OSA diagnosed by polysomnography who underwent PCI

Comparison

Treated OSA vs untreated OSA

Design

Retrospective cohort study

Follow-up

5 years

Authors

ACAndrew CassarMater Dei Hospital TMTimothy I. MorgenthalerMayo Clinic RLRyan J. LennonInterventional Cardiology

Discussion

Member takes

Implication

Treatment of obstructive sleep apnea in patients undergoing percutaneous coronary intervention is associated with a significant reduction in cardiac death at 5 years.

Key Points

To determine whether treatment for obstructive sleep apnea improves survival and clinical outcomes in patients undergoing percutaneous coronary intervention.
Conducted a retrospective cohort study of 371 patients diagnosed with obstructive sleep apnea via polysomnography (apnea-hypopnea index ≥15) between 1992 and 2004 who subsequently had percutaneous coronary intervention.
Stratified patients into treated (n = 175) and untreated (n = 196) cohorts to assess 5-year cardiac death, general mortality, major adverse cardiac events, and major adverse cardiac or cerebrovascular events.
Treated patients experienced a significantly lower rate of cardiac death at 5 years compared to untreated patients (3% [95% CI, 0% to 6%] vs. 10% [95% CI, 5% to 14%], p = 0.027), with a trend toward decreased all-cause mortality (p = 0.058).
No statistically significant differences occurred between groups for major adverse cardiac events (p = 0.91) or major adverse cardiac or cerebrovascular events (p = 0.96).

Study Design

Type

Cohort (n=371)

Structured PICO

Does treatment for obstructive sleep apnea reduce cardiac death and adverse events in patients who have undergone percutaneous coronary intervention?

Population

371 patients with obstructive sleep apnea (apnea-hypopnea index ≥15) who subsequently underwent percutaneous coronary intervention, followed for 5 years.

Exposure

Treatment for obstructive sleep apnea

Comparator

Untreated obstructive sleep apnea

Outcome

Cardiac death, general mortality, major adverse cardiac events (MACE) (severe angina, myocardial infarction, PCI, coronary artery bypass grafting, or death), and major adverse cardiac or cerebrovascular events (MACCE)hard clinical

Main Result

Absolute Event Rate: 3% vs 10%

p-value: p=0.027

Treatment of obstructive sleep apnea in patients undergoing percutaneous coronary intervention is associated with a significant reduction in cardiac death at 5 years.

Cite This Study

Cassar et al. (2007) conducted a cohort in Obstructive sleep apnea and percutaneous coronary intervention (n=371). Treatment for obstructive sleep apnea vs. Untreated obstructive sleep apnea was evaluated on cardiac death (p=0.027). Treatment of obstructive sleep apnea in patients who underwent PCI was associated with a significantly lower rate of cardiac death at 5 years compared to untreated patients (3% vs. 10%, p=0.027).

synapsesocial.com/papers/69f6bea9948acd347ea349b8 https://doi.org/10.1016/j.jacc.2007.06.028

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Implication

Treatment of obstructive sleep apnea in patients undergoing percutaneous coronary intervention is associated with a significant reduction in cardiac death at 5 years.

Treatment of Obstructive Sleep Apnea Is Associated With Decreased Cardiac Death After Percutaneous Coronary Intervention

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Treatment of Obstructive Sleep Apnea Is Associated With Decreased Cardiac Death After Percutaneous Coronary Intervention

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Main Result

Cite This Study

Also Consider

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