Key result
PIONEER IV trial report provides study acknowledgements without reporting clinical outcome data.
RCT
Yes
QFR simplifies physiological PCI guidance without outcome compromise; extends randomized evidence as noninferior alternative to invasive usual care.[[1]](https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag174/8526219)[[2]](https://medisimaging.
Funding This study was sponsored by the University of Galway with a research grant from Sino Medical Sciences Technology Inc. Acknowledgement The PIONEER IV trial was sponsored by the University of Galway. We thank the members of the DSMB (Prof. Pedro Lemos, Prof. Dominick Angiolillo, and Dr. Alberto Alvarez-Iglesias) and the Clinical Events Committee (Prof. Scot Garg, Dr. Maik Grundeken, and Dr. Javaid Iqbal) for their contributions to ensuring the safe conduct of the trial and adjudication of events. We are grateful to Medis Medical Imaging for technical support to the sites and the central core laboratory. We also deeply appreciate the intellectual contributions of our visiting scholars, Dr. Gonçalo Costa and Dr. Jacopo Farina, and the guidance of our steering committee members, Prof. William Wijns and Prof. Andrew Smith. Finally, we thank the PIONEER IV coordination, data management, and trial safety teams for their dedication, and we are indebted to the participating patients and investigators.
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Serruys et al. (2026) conducted an RCT in Patients undergoing percutaneous coronary intervention. Angiography-derived fractional flow reserve-guided percutaneous coronary intervention vs. Usual care-guided percutaneous coronary intervention was evaluated. The provided abstract contains only funding and acknowledgement information, with no clinical results reported for the PIONEER IV trial.
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