deprotonation. This suggests the catalytic mechanism is distinct among the canonical PLP-dependent decarboxylative C-C bond forming enzymes. Genome mining of LhnE homologues also implicated the existence of previously unknown norstatine natural products. Furthermore, LhnE was successfully applied to the biocatalytic synthesis of non-natural norstatines. Together, this study provides novel insights into PLP-dependent C-C bond formation and establishes a biocatalytic route for streamlined access to norstatine pharmacophores.
Mizutani et al. (Fri,) studied this question.