What question did this study set out to answer?

To investigate the relationship between transcriptional activity and H3K4me3 modification in inducible human genes.

May 3, 20260 citations

Temporal analysis of two inducible human genes reveals post-transcriptional H3K4me3 deposition.

KWKomal Paresh Walvekar SCSabarinadh Chilaka

Key Points

To investigate the relationship between transcriptional activity and H3K4me3 modification in inducible human genes.
Analyzed human genes with inducible expression under various conditions.
Examined H3K4me3 deposition after transcriptional inhibition.
H3K4me3 persists even when transcription is inhibited, indicating its maintenance is uncoupled from transcription.
Demonstrated that H3K4me3 acts as a consequence of transcriptional activity rather than a trigger.

Abstract

locus, H3K4me3 persists after transcriptional inhibition, indicating temporal uncoupling between transcription and H3K4me3 maintenance. Our findings provide a detailed kinetic characterization of H3K4me3 loading and suggest that at these inducible genes, this modification serves as a consequence of, rather than a trigger for, transcriptional initiation.

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