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Uncovers the role of H3K4me3 in gene induction, suggesting that it is a consequence of transcriptional activity.
locus, H3K4me3 persists after transcriptional inhibition, indicating temporal uncoupling between transcription and H3K4me3 maintenance. Our findings provide a detailed kinetic characterization of H3K4me3 loading and suggest that at these inducible genes, this modification serves as a consequence of, rather than a trigger for, transcriptional initiation.
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Walvekar et al. (2026) studied this question.
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