What question did this study set out to answer?

To evaluate the efficacy of panaxynol in alleviating chemotherapy-induced intestinal mucositis in murine models.

May 3, 20260 citations

Panaxynol mitigates chemotherapy-induced intestinal mucositis by improving the colonic microenvironment in murine models.

BBBrooke M. BullardUniversity of South Carolina BVBrandon N. VanderVeenAtrium Health Wake Forest Baptist TCThomas D. CardaciUniversity of South Carolina

Key Points

To evaluate the efficacy of panaxynol in alleviating chemotherapy-induced intestinal mucositis in murine models.
Utilized murine models to assess the effects of panaxynol on chemotherapy-induced intestinal mucositis.
Analyzed the colonic microenvironment and its response to 5FU treatment.
Panaxynol treatment improved the colonic microenvironment in mice treated with 5FU.
Reduction in intestinal mucositis symptoms was observed with panaxynol administration.

Abstract

abundance was primarily influenced by 5FU treatment. These preclinical findings support the potential of panaxynol as a therapeutic candidate for the treatment of CIM and highlight the importance of considering sex as a biological variable.

AI से पूछें

Bookmark

View Full Paper