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The aim is to explore the effects and underlying mechanisms of salidroside-pretreated hDPSCs on brain damage caused by hypoxic-ischaemic events in neonatal rats.

May 3, 20260 citations

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Sal-hDPSCs Transplantation Alleviates Hypoxic-Ischaemic Ferroptosis in Neonatal Rats Via the FSP1-CoQ10 Axis.

KXKang XuWeifang Medical University YLYan LiWeifang Medical University SGShujun GaoWeifang Medical University

Key Points

The aim is to explore the effects and underlying mechanisms of salidroside-pretreated hDPSCs on brain damage caused by hypoxic-ischaemic events in neonatal rats.
Evaluation of the therapeutic effects of Sal-hDPSCs on hypoxic-ischaemic brain damage in neonatal rats.
Measurement of FSP1 and GPX4 expression levels in response to salidroside and hypoxic conditions.
Sal-hDPSCs significantly improved outcomes in hypoxic-ischaemic brain damage as shown in neonatal rat models.
Increased expression of GPX4 and FSP1 was observed in treated rat brains, linked to reduced ferroptosis.
Effects of the treatment were negated by the inhibition of FSP1, indicating its critical role.

Abstract

OBJECTIVE: To investigate the therapeutic effects and mechanisms of salidroside-pretreated human dental pulp stem cells (Sal-hDPSCs) on hypoxic-ischaemic brain damage (HIBD) in neonatal rats, providing a scientific basis for clinical application of hDPSCs. METHODS: and GPX4/FSP1 expression. RESULTS: in OGD-exposed PC12 cells; these effects were abolished by iFSP1. CONCLUSION: axis.

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Sal-hDPSCs Transplantation Alleviates Hypoxic-Ischaemic Ferroptosis in Neonatal Rats Via the FSP1-CoQ10 Axis.

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