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May 3, 2026Frontiers in MicrobiologyOpen Access

Hybrid plasmids: genetic diversity and hypervirulent phenotype of Klebsiella pneumoniae

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Authors

SKSvetlana KovalchukAAAnna ArkhipovaAMAlexandra Melikhova

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Overview

Randomized trial observed genetic diversity and virulence in Klebsiella pneumoniae, suggesting a need for further research.

Key Points

  • The aim is to investigate the relationship between hybrid plasmids and hypervirulence in Klebsiella pneumoniae isolates.
  • Conducted whole-genome sequencing of 32 K. pneumoniae isolates from patients and environmental surfaces.
  • Assessed the virulence of 7 isolates using a mouse lethality assay.
  • Performed cluster analysis of 295 global hybrid plasmids based on nucleotide sequences.
  • 27 out of 32 isolates carried hybrid plasmids with virulence genes and antibiotic resistance genes.
  • The LD50 values for tested isolates were greater than 10^6 CFU, indicating comparable lethality to classical K. pneumoniae.
  • Identified 8 clusters of hybrid plasmids correlated with replicon type, antibiotic resistance genes, and virulence genes.

Cite This Study

Kovalchuk et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5ac8071d4f1bdfc640chttps://doi.org/10.3389/fmicb.2026.1768089
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