Size-Tunable Hemoglobin Oxygen Carriers with Antioxidant and Pro-Angiogenic Functions for Wound Healing

Yu Zhang (12946); Honglei Zhu; Wang Qinqi; Leijiao Li; Liana Shestakova; Youry Ostrovsky; Xincui Shi Shi; Yuan Cui; Wenliang Li

doi:10.1039/d6cc02127a

January 1, 2026Chemical Communications

Size-Tunable Hemoglobin Oxygen Carriers with Antioxidant and Pro-Angiogenic Functions for Wound Healing

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Key Points

The aim is to develop hemoglobin-based oxygen carriers that improve wound healing through antioxidant and angiogenic functions.
Synthesis of size-tunable Hb-Oxy via a template-assisted strategy
Functionalization of Hb-Oxy with caffeic acid (CA)
Evaluation of oxygen affinity using P50 measurements.
Optimized Hb-CA building blocks achieved a P50 of 35.84 mmHg and >99% encapsulation efficiency.
Demonstrated antioxidant and pro-angiogenic properties in vitro and in vivo models.
Size-tunable properties led to improved wound healing outcomes compared to unmodified carriers.

Implication

Demonstrates enhanced wound healing with size-tunable hemoglobin oxygen carriers, suggesting new therapeutic approaches.

Abstract

Size-tunable hemoglobin-based oxygen carriers (Hb-Oxy) were synthesized via a template-assisted strategy and functionalized with caffeic acid (CA). The optimized Hb-CA building blocks exhibit an ideal P50 (35.84 mmHg) and >99%...

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Cite This Study

(12946) et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5cf8071d4f1bdfc6703 https://doi.org/10.1039/d6cc02127a

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Size-Tunable Hemoglobin Oxygen Carriers with Antioxidant and Pro-Angiogenic Functions for Wound Healing

Key Points

Implication

Abstract

Discussion

Cite This Study

Size-Tunable Hemoglobin Oxygen Carriers with Antioxidant and Pro-Angiogenic Functions for Wound Healing

Key Points

Implication

Abstract

Discussion

Cite This Study

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