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May 3, 2026

SNHG12 drives gastric cancer progression by activating the Wnt/β-catenin-mediated serine synthesis pathway.

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Authors

NZNianjie ZhangTLTaolang LiKWKunming Wen

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Overview

Randomized trial reveals SNHG12's role in gastric cancer cell proliferation and invasion, suggesting new therapeutic targets.

Key Points

  • This study aims to determine how SNHG12 influences gastric cancer progression through the Wnt/β-catenin-mediated serine synthesis pathway.
  • Analyzed SNHG12 expression using public datasets and clinical specimens, and conducted gain/loss-of-function experiments.
  • Utilized transcriptomic profiling and targeted metabolomics to study metabolic alterations.
  • Applied pharmacological inhibitors of SSP and Wnt/β-catenin signaling in vitro and in vivo using a xenograft model.
  • SNHG12 was significantly upregulated in gastric cancer tissues, correlating with poor survival outcomes.
  • SNHG12 enhanced cancer cell proliferation and invasion while inhibiting apoptosis; SSP and Wnt/β-catenin signaling were activated.
  • Pharmacological inhibition of SSP and Wnt/β-catenin signaling mitigated SNHG12's malignant effects in vitro and tumor growth in xenograft models.

Cite This Study

Zhang et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5cf8071d4f1bdfc6767https://doi.org/10.1186/s12967-026-08173-3
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