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Synapse
May 3, 2026

Neuroendocrine and neural control of bone mass in health and disease.

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Authors

MZMone ZaidiSKSe-Min KimVRVitaly Ryu

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Overview

Review highlights neural and hormonal regulation of bone mass, revealing implications for disease treatment.

Key Points

  • To explore the roles of neuroendocrine and neural mechanisms in bone mass regulation and disease.
  • Reviewed recent studies on the central nervous system's role in skeletal regulation.
  • Examined the neurohormonal amplitude-modulated and frequency-modulated control systems.
  • Identified candidate therapeutics targeting dysregulated bone remodeling.
  • Increased understanding of the central nervous system's influence on bone mass.
  • Identified dysfunction in AM and FM control systems leads to conditions like osteoporosis.
  • Uncovered potential therapeutic targets for improving bone health.

Cite This Study

Zaidi et al. (2026) studied this question.

synapsesocial.com/papers/69f6e5f38071d4f1bdfc68c3https://doi.org/10.1172/jci203623
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