The severity of post-infarction edema suggests a bimodal pattern, whereas the extent does not.

Fig. 1. Schematic overview of the study design and cardiovascular magnetic resonance sequences acquired. In group 1, a total of nine pigs were included with two pigs excluded due to fatal arrhythmias. Seven pigs were included in the final analysis and were imaged at baseline followed by 40 min infarct/reperfusion. Serial imaging following reperfusion was performed at 120 min, 24 h and 7 days. In a separate group (group 2) four pigs were imaged at day 4 followed by histopathological assessment of MaR using Evans blue dye. MaR myocardium at risk

Fig. 2. In panel A, an example depicting MaR using CMR contrast-enhanced SSFP images (top row) and histopathological staining with Evans blue dye (middle row) and late gadolinium enhancement images is shown. In the middle row blue areas represent the remote myocardium and reddish area the MaR. In panel B, the relationship between myocardium at risk (MaR) using histopathology with Evans blue dye and CMR contrast-enhanced SSFP images. Bland–Altman analysis demonstrates a bias of 3±5%MaR. Dashed lines = 95% limits of agreement. MaR myocardium at risk, CMR cardiovascular magnetic resonance

Fig. 3. This figure shows imaging at baseline and following ischemia/reperfusion at three time points with measures of severity of edema in myocardium at risk (MaR) using two T2- mapping sequences (panels A and B) and measures of extent of MaR using contrast-enhanced SSFP (panel C), T2 STIR (panel D) and infarct size by late gadolinium enhancement imaging (panel E). Two examples are shown from two different animals. A. T2 relaxation times using a T2-SSFP mapping sequence (T2 mappingSSFP). There is a significantly lower T2 at 24 h compared to 120 min and seven days. B. T2 relaxation times using a T2-TSE mapping sequence (T2 mappingTSE). Similar results are seen as for T2 mappingSSFP in panel A. C. Extent of MaR using CE-SSFP demonstrates that there is no bimodal pattern of the extent of MaR over seven days but rather a decline in extent of MaR from 2 h to seven days post reperfusion. D. Extent of MaR using T2-STIR demonstrates similar results as CE-SSFP in panel C. D. Infarct size by late gadolinium enhancement imaging demonstrating smaller infarct day 7 compared to other time points. Statistical significance was determined using Holm-adjusted pairwise comparisons based on linear…