Following acute experimental MI, the extent of myocardium at risk gradually decreased from 120 minutes to 7 days (29% to 24% LVM), whereas the severity of edema suggested a bimodal pattern.
Does the severity and extent of post-infarction edema follow a bimodal pattern on CMR imaging during the first week following acute experimental MI?
In an experimental MI model, the severity of post-infarction edema follows a bimodal pattern over the first week, whereas the extent of edema gradually decreases.
BACKGROUND: Preclinical and clinical data following acute myocardial infarction (MI) have shown conflicting results whether a bimodal pattern of edematous myocardium at risk (MaR) on CMR imaging during the first week exists or not. The objective was to assess the dynamics of MaR following acute experimental MI using a comprehensive cardiovascular magnetic resonance (CMR) protocol. METHODS: ), and a T2w short-tau inversion recovery (T2-STIR) sequence. After contrast administration, CE-SSFP and LGE images were acquired. The severity of MaR was defined as the T2 relaxation on T2 maps and extent of MaR as percentage of edematous myocardium on CE-SSFP and T2-STIR images. RESULTS: :67±12ms). The extent of MaR showed a gradual decrease between 120minutes and 24hours on CE-SSFP (29±10 vs 26±9%LVM) and at 7 days compared to both previous time points (CE-SSFP: 24±11%LVM). CONCLUSION: The severity of edema within the MaR following acute MI suggests a bimodal pattern, whereas the extent of MaR does not.
Jablonowski et al. (Tue,) conducted a other in Acute myocardial infarction (MI). Cardiovascular magnetic resonance (CMR) was evaluated on Severity (T2 relaxation) and extent (%LVM) of myocardium at risk (MaR). Following acute experimental MI, the extent of myocardium at risk gradually decreased from 120 minutes to 7 days (29% to 24% LVM), whereas the severity of edema suggested a bimodal pattern.