GluK1 kainate receptors in parvalbumin interneurons modulate cortico-hippocampal network dynamics during social behavior.

Jun Kyu Rhee; Simo Ojanen; Tiina Paakkunainen; Aino Vesikansa; Zoia Kharybina; Joni Haikonen; Rahaf Keskinen; Tomi Taira; Sari E Lauri

doi:10.1038/s41398-026-04060-z

April 30, 2026

GluK1 kainate receptors in parvalbumin interneurons modulate cortico-hippocampal network dynamics during social behavior.

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Key Points

This research aims to explore how GluK1 kainate receptors in parvalbumin interneurons affect cortico-hippocampal network dynamics during social behavior.
Utilized mice to examine the effects of GluK1 receptor dysfunction on social discrimination.
Analyzed the interaction between interneurons and network dynamics in response to social stimuli.
GluK1 dysfunction led to significant impairments in social discrimination abilities.
Altered neural dynamics within the cortico-hippocampal network were observed during social interactions.

Implication

Examines the role of GluK1 receptors in social behavior, indicating their importance in neuropsychiatric disorders.

Abstract

mice compromise social discrimination and shed light on the neurobiological mechanisms by which GluK1 dysfunction may contribute to neuropsychiatric disorders.

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Cite This Study

Rhee et al. (2026) studied this question.

synapsesocial.com/papers/69f6e6648071d4f1bdfc718a https://doi.org/10.1038/s41398-026-04060-z

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GluK1 kainate receptors in parvalbumin interneurons modulate cortico-hippocampal network dynamics during social behavior.

Key Points

Implication

Abstract

Discussion

Cite This Study

GluK1 kainate receptors in parvalbumin interneurons modulate cortico-hippocampal network dynamics during social behavior.

Key Points

Implication

Abstract

Discussion

Cite This Study

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