Comparing The Levels of Serum Netrin-1, Nesfatin-1 and Adropin in Subclinical and Overt Hypothyroid Patients

May 26, 2025

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The study aims to evaluate serum concentrations of netrin-1, nesfatin-1, and adropin in overt and subclinical hypothyroid patients and their relationship with thyroid function tests and metabolic parameters.
Single-center cross-sectional study with 83 participants including 27 overt hypothyroid, 29 subclinical hypothyroid, and 27 control subjects.
Measurements included body mass index, waist circumference, thyroid hormones, autoantibodies, and metabolic parameters.
Statistical analysis was performed to compare serum levels across groups.
Body mass index, waist circumference, TSH, anti-TPO, fasting blood sugar, total cholesterol, and LDL levels were significantly higher in the overt hypothyroid group compared to controls (p=0.014, p=0.007 respectively).

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Compares serum levels of netrin-1, nesfatin-1, and adropin in hypothyroidism, suggesting their role in metabolic regulation.

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Gemci et al. (2025) studied this question.

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