Gingipain proteases from the bacterium Porphyromonas gingivalis confer protection against airway viral infection.

Carlos J Rodriguez Hernandez; Alonso Cruz-Cruz; Chandra L. Shrestha; Marina Terekhova; Phylip Chen; John Perpich; Barbara Potempa; Katherine Carey; Michelle Rohlfing; Mark E. Peeples; Mitchell H. Grayson; Jan Potempa; Maxim Artyomov; Richard J Lamont; Juhi Bagaitkar

doi:10.1073/pnas.2503100123

May 5, 2026

Gingipain proteases from the bacterium Porphyromonas gingivalis confer protection against airway viral infection.

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Key Points

The aim is to evaluate how gingipain proteases influence host responses to viral infections.
Gingipain proteases were tested for their ability to inhibit host interferon responses.
The impact of these proteases on viral infectious capacity was assessed.
Gingipain proteases significantly inhibited host IFN responses.
Proteases preemptively reduced viral infectious capacity, providing robust protection against respiratory infections.

Implication

Demonstrates gingipain proteases reduce viral infection severity in hosts, suggesting therapeutic potential.

Abstract

can significantly inhibit host IFN responses, its proteases preemptively reduce viral infectious capacity, protecting the host from severe damage associated with respiratory infections.

Discussion

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Cite This Study

Hernandez et al. (2026) studied this question.

synapsesocial.com/papers/69f6e6ab8071d4f1bdfc76d1 https://doi.org/10.1073/pnas.2503100123

View Full Paper

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Gingipain proteases from the bacterium Porphyromonas gingivalis confer protection against airway viral infection.

Key Points

Implication

Abstract

Discussion

Cite This Study

Gingipain proteases from the bacterium Porphyromonas gingivalis confer protection against airway viral infection.

Key Points

Implication

Abstract

Discussion

Cite This Study

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