Research explores how covalent warheads influence GST-catalyzed glutathione conjugation, suggesting new optimization strategies for therapeutics.
values correlate closely with compound half-lives in human liver cytosol. Together, these findings establish GST susceptibility as a structurally tunable determinant of metabolic GSH conjugation and provide new principles for the optimization of TCIs.
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Mader et al. (2026) studied this question.
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