Lactylation of HIF-1α at K172 drives HIF-1 complex assembly to promote hypoxia-induced immune evasion in esophageal squamous cell carcinoma.

Key Points

• The study aims to elucidate the role of HIF-1α K172 lactylation in hypoxia-mediated immune evasion in esophageal squamous cell carcinoma.
• Identified lactylation at K172 of HIF-1α in esophageal squamous cell carcinoma tissues.
• Investigated the impact on T cell cytotoxicity and immune response due to hypoxic conditions.
• Proposed lactylation as a potential therapeutic strategy to enhance immunotherapy outcomes.
• HIF-1α K172 lactylation significantly correlates with reduced T cell cytotoxicity.
• Observed immune evasion mechanisms are tightly linked to lactylation levels.
• Suggests targeting HIF-1α lactylation could enhance the effectiveness of immunotherapy.