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May 1, 2026

Chronic lymphocytic leukemia with IGH::BCL3-translocation is characterized by a homogeneous and distinct genetic and epigenetic landscape.

Cosima Drewes C Camacho López Juan Emilio Martínez-Manjón Nnamdi Okeke Billy Jebaraj Susanne Bens Björn Brändl Martin J S Dyer Barbara Eichhorst Anja Fischer Kirsten Fischer Sandra Robrecht Michael Hallek Selina Glaser Sina Hillebrecht Sandrine Jayne Helene Kretzmer Anja Mottok Franz-Josef Müller Christof Schneider Ole Ammerpohl Coral del Val Stephan Stilgenbauer Eugen Tausch Reiner Siebert

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Key Points

The study aims to characterize the genetic and epigenetic features of chronic lymphocytic leukemia (CLL) associated with IGH:BCL3 translocation.
Analysis of genetic and epigenetic profiles in chronic lymphocytic leukemia cases with IGH:BCL3 translocation.
Comparison of findings against other B-cell neoplasms to identify distinct features.
Identified a homogeneous genetic landscape in CLL with IGH:BCL3 translocation.
Characterized distinct epigenetic markers that differentiate these leukemias from other types.

Implication

Reveals distinct genetic and epigenetic characteristics in B-cell neoplasms, highlighting their uniqueness.

Abstract

leukemic B-cell neoplasms to be a biological distinct type within the spectrum of mature lymphatic leukemia/CLL.

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Cite This Study

Drewes et al. (2026) studied this question.

synapsesocial.com/papers/69f6e6e68071d4f1bdfc78d3 https://doi.org/10.1002/hem3.70354

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Abstract P13: Genetic and epigenetic characterization of B-cell chronic lymphocytic leukemia with <i>IG</i>::<i>BCL3</i>-translocation provides evidence for a distinct biological entity2024
2The spectrum of immunoglobulin heavy chain enhancer hijacking in chronic lymphocytic leukemiaOriginal Research · 2026
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4Chronic lymphocytic leukemia with IGH/BCL2 fusion and clonal heterogeneity: phenotypic and molecular profiling analysis of a rare caseOriginal Research · 2026
5IGLV3-21R110 identifies an aggressive biological subtype of chronic lymphocytic leukemia with intermediate epigeneticsOriginal Research · 2020 · 87 citations