Prognostic value of Ki67 in phyllodes tumor of the breast: A systematic review and meta‑analysis

status. All five studies scored 8 points on the Newcastle-Ottawa Scale, equivalent to 'good' quality according to Agency for Healthcare Research and Quality standards, and no significant publication bias was noted. This was the first meta-analysis of the predictive value of Ki67 in PT of the breast. A relatively high Ki67 index (>10%) is associated with recurrence. It is timely to re-evaluate the prognostic value of Ki67 in large retrospective cohorts with long follow-up to firmly establish whether it could contribute to identifying patients at risk of recurrence, particularly those with histologically benign disease. Doing so could impact clinical practice by refining follow-up recommendations based on quality evidence.