Highly Sensitive and Biocompatible Microsensor for Selective Dynamic Monitoring of Dopamine in Rat Brain

in the detection ranges of 0.02-0.5 and 0.5-20 μM with a low limit of detection of 9.2 nM. Also, the microsensor shows excellent selectivity, good sensing stability, repeatability, and reproducibility. In addition, the highly hydrophilic and negative-charged pTA inhibits the nonspecific adsorption of hydrophobic proteins, which endows the microsensor with good antifouling ability. Moreover, DA dynamics in rat brain were successfully monitored in real time, and the selective sensing ability of the microsensor in vivo was also demonstrated. The present study provides a new method for selective dynamics monitoring of DA in the brain, which would help to better understand the pathological and physiological functions of DA.