January 4, 2017Open Access

Dual-specificity phosphatase 5 controls the localized inhibition, propagation, and transforming potential of ERK signaling

AKAndrew M. KidgerBabraham Institute LRLinda RushworthThe University of Notre Dame Australia JSJulia StellzigUniversity of Dundee

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Abstract

-induced ERK hyperactivation and cellular senescence. Thus, feedback interactions within the ERK pathway can regulate cell proliferation and transformation, and suggest oncogene-specific roles for DUSP5 in controlling ERK signaling and cell fate.

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