Why the study?
Recent studies have shown that perivascular adipose tissue is implicated in endothelial dysfunction, atherosclerosis progression, and insulin resistance in cardiovascular diseases and type 2 diabetes mellitus.
Perivascular adipose tissue represents a potential therapeutic target to restore endothelial function and reduce global cardiovascular risk in patients with CVD and T2DM.
Cardiovascular diseases (CVDs) and type 2 diabetes mellitus (T2DM) are two of the four major chronic non-communicable diseases (NCDs) representing the leading cause of death worldwide. Several studies demonstrate that endothelial dysfunction (ED) plays a central role in the pathogenesis of these chronic diseases. Although it is well known that systemic chronic inflammation and oxidative stress are primarily involved in the development of ED, recent studies have shown that perivascular adipose tissue (PVAT) is implicated in its pathogenesis, also contributing to the progression of atherosclerosis and to insulin resistance (IR). In this review, we describe the relationship between PVAT and ED, and we also analyse the role of PVAT in the pathogenesis of CVDs and T2DM, further assessing its potential therapeutic target with the aim of restoring normal ED and reducing global cardiovascular risk.
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Valentini et al. (2023) studied this question.
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