Background: Hen’s egg allergy (HEA) is a prevalent food allergy in infants and young children. This study aimed to identify the progression of HEA over 48 months and identify factors that may predict its resolution. Methods: This prospective study was conducted on infants with HEA. We collected demographic information, clinical symptoms, and potential predictive factors. Skin prick tests were performed, and the infants were monitored over 48 months, with the resolution of allergy confirmed by successful egg ingestion. Results: A total of 121 infants were initially enrolled, of whom 98 completed the 48-month follow-up. By the end of follow-up, 80.6% developed tolerance, while 19.4% had persistent allergy. Kaplan–Meier analysis showed a median time to tolerance of 24 months, with 25%, 50%, and 75% of infants achieving tolerance by 18, 24, and 36 months, respectively. A smaller skin prick test wheal size (<10 mm) was associated with earlier tolerance acquisition ( P = 0.038), whereas erythema size was not associated with time to tolerance ( P = 0.507). Conclusion: While many infants with HEA outgrow their allergy by the age of 4, a significant minority remains affected. The size of the wheal may serve as a critical indicator of the likelihood of persistent allergy.
Moghtaderi et al. (Wed,) studied this question.