Single-molecule Detection of Amino Acid Phosphorylation using electron tunnelling currents: Toward Neurodegenerative Disease Diagnosis

Yuki Komoto; Wataru Takahagi; Takahito Ohshiro; Sumire Nishihata; Kosuke Fujishima; Masateru Taniguchi

doi:10.1039/d6nr00687f

January 1, 2026NanoscaleOpen Access

Single-molecule Detection of Amino Acid Phosphorylation using electron tunnelling currents: Toward Neurodegenerative Disease Diagnosis

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Key Points

This research focuses on the detection of amino acid phosphorylation and its implications for diagnosing neurodegenerative diseases.
Utilized electron tunnelling currents for single-molecule detection of phosphorylation.
Investigated the link between phosphorylation dysregulation and neurodegenerative diseases.
Identified phosphorylation changes associated with neurodegenerative disease markers.
Demonstrated the potential for improved diagnostic techniques targeting phosphorylation.

Implication

Demonstrates detection of phosphorylation in neurodegenerative diseases, suggesting diagnostic potential.

Abstract

Protein phosphorylation is one of the most prevalent post-translational modifications regulating biological functions, and its dysregulation is closely associated with neurodegenerative diseases such as Alzheimer's and Parkinson's disease. Despite extensive...

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Cite This Study

Komoto et al. (2026) studied this question.

synapsesocial.com/papers/69f837003ed186a739981227 https://doi.org/10.1039/d6nr00687f

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Single-molecule Detection of Amino Acid Phosphorylation using electron tunnelling currents: Toward Neurodegenerative Disease Diagnosis

Key Points

Implication

Abstract

Discussion

Cite This Study

Single-molecule Detection of Amino Acid Phosphorylation using electron tunnelling currents: Toward Neurodegenerative Disease Diagnosis

Key Points

Implication

Abstract

Discussion

Cite This Study

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