Simultaneous Determination of Eight Cannabinoids in Hemp‑Based Dietary Supplements via an Optimized SE–HPLC‑PDA Workflow Integrating Chemometric Evaluation

Radosław Porada; Monika Wójcik; Małgorzata Herman; Wojciech Piekoszewski

doi:10.1039/d6ay00387g

January 1, 2026Analytical Methods

Simultaneous Determination of Eight Cannabinoids in Hemp‑Based Dietary Supplements via an Optimized SE–HPLC‑PDA Workflow Integrating Chemometric Evaluation

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Key Points

This research aims to enhance methods for analyzing cannabinoids in hemp-based dietary supplements for better quality control.
Developed a simultaneous determination workflow for eight cannabinoids using optimized HPLC with photodiode array detection.
Integrated chemometric evaluation to analyze data efficiently and improve accuracy of results.
Evaluated various sample preparation techniques to identify the most effective method.
Achieved accurate measurement of all eight cannabinoids with minimal sample preparation time.
Demonstrated improved precision and recovery rates for cannabinoid quantification in hemp supplements.
Results indicate a significant enhancement in the analytical workflow's efficiency, suggesting potential for broader applications.

Implication

Evaluates cannabinoid levels in hemp dietary supplements, suggesting improved quality control methods.

Abstract

The growing availability of hemp-based dietary supplements requires improvement of analytical methods and sample preparation for quality control of such products. This work presents a simple and efficient workflow involving...

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Cite This Study

Porada et al. (2026) studied this question.

synapsesocial.com/papers/69f837003ed186a739981248 https://doi.org/10.1039/d6ay00387g

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Simultaneous Determination of Eight Cannabinoids in Hemp‑Based Dietary Supplements via an Optimized SE–HPLC‑PDA Workflow Integrating Chemometric Evaluation

Key Points

Implication

Abstract

Discussion

Cite This Study

Simultaneous Determination of Eight Cannabinoids in Hemp‑Based Dietary Supplements via an Optimized SE–HPLC‑PDA Workflow Integrating Chemometric Evaluation

Key Points

Implication

Abstract

Discussion

Cite This Study

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