Cascade reaction of 2-halo-4-alkenyloxazoles with arynes: a switchable divergent synthesis of 2-arylnaphtho[2,1- d ]oxazoles, N -acylnaphthylamines, and α-halonaphthalenes

Y M Wang; Yaoyao Mei; Guilin Li; Feng Sha; Xinyan Wu

doi:10.1039/d6qo00276e

January 1, 2026Organic Chemistry Frontiers

Cascade reaction of 2-halo-4-alkenyloxazoles with arynes: a switchable divergent synthesis of 2-arylnaphtho[2,1- d ]oxazoles, N -acylnaphthylamines, and α-halonaphthalenes

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Key Points

This research aims to explore a cascade reaction to synthesize multiple chemical compounds with high selectivity.
Utilized a novel cascade reaction of 2-halo-4-alkenyloxazoles with arynes.
Tuned reaction conditions to achieve different product outcomes.
Generated 2-arylnaphtho[2,1-d]oxazoles, N-acylnaphthylamines, and α-halonaphthalenes.
Achieved high selectivity for 2-arylnaphtho[2,1-d]oxazoles and N-acylnaphthylamines by adjusting reaction conditions.
Successfully produced α-halonaphthalenes as an additional product in the cascade.

Implication

Novel cascade reaction synthesizes diverse compounds in high selectivity, suggesting flexibility in chemical reactions.

Abstract

A novel cascade reaction of 2-halo-4-alkenyloxazoles with arynes affords switchable divergent synthesis of 2-arylnaphtho[2,1- d ]oxazoles, N -acylnaphthylamines, and α -halonaphthalenes, with high selectivity by tuning reaction conditions.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69f837233ed186a7399813c5 https://doi.org/10.1039/d6qo00276e

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Cascade reaction of 2-halo-4-alkenyloxazoles with arynes: a switchable divergent synthesis of 2-arylnaphtho[2,1- d ]oxazoles, N -acylnaphthylamines, and α-halonaphthalenes

Key Points

Implication

Abstract

Discussion

Cite This Study

Cascade reaction of 2-halo-4-alkenyloxazoles with arynes: a switchable divergent synthesis of 2-arylnaphtho[2,1- d ]oxazoles, N -acylnaphthylamines, and α-halonaphthalenes

Key Points

Implication

Abstract

Discussion

Cite This Study

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