Local application of otoprotective compounds other than sodium thiosulfate to prevent cisplatin-induced hearing loss: a systematic review.

Amirhossein Masroor; Nienke Streefkerk; Martine van Grotel; James I. Geller; Marc Ansari; Éric Bouffet; Archie Bleyer; Brice Fresneau; Michael Sullivan; Kristin Knight; Per Kogner; Rudolf Maibach; Allison F. O’Neill; Vassilios Papadakis; Kaukab Rajput; Penelope Brock; Gareth J. Veal; Alexander E Hoetink; Alwin D R Huitema; Marry M Van Den Heuvel-Eibrink

doi:10.1080/10717544.2026.2665892

Key Points

To evaluate the effectiveness of local otoprotective compounds other than sodium thiosulfate in preventing cisplatin-induced hearing loss.
Analyzed data from two clinical trials and one randomized controlled trial (RCT).
Focused on the efficacy and safety of n-acetylcysteine.
Reviewed studies regarding alternative otoprotective agents for pediatric patients.
N-acetylcysteine showed minimal effectiveness in the RCT and one clinical study.
No available studies reliably replace systemic sodium thiosulfate as a safe and effective agent in pediatrics.
Calls for further research into dosage, delivery method, and timing of otoprotective agents.

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Implication

Systematic review finds limited effectiveness of alternative otoprotective agents for kids, suggesting future research is needed.

Abstract

-acetylcysteine was investigated in two clinical trials and one RCT and was minimally effective in the RCT and in one clinical study. Our review did not identify available studies of local alternative otoprotective agents that could reliably replace systemic STS in terms of safety and efficacy for pediatric patients. Further research on the optimal dosage, delivery method, and timing of otoprotective agents is needed.

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Masroor et al. (2026) studied this question.

synapsesocial.com/papers/69f837233ed186a739981404 https://doi.org/10.1080/10717544.2026.2665892

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Local application of otoprotective compounds other than sodium thiosulfate to prevent cisplatin-induced hearing loss: a systematic review.

Key Points

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Implication

Abstract

Discussion

Cite This Study

Local application of otoprotective compounds other than sodium thiosulfate to prevent cisplatin-induced hearing loss: a systematic review.

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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