Climate-Driven Modulation of Plant Secondary Metabolites: Implications for Medicinal Quality, Standardization, and Therapeutic Efficacy

February 23, 2026

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Key Points

To assess how current climate change conditions affect the biosynthesis and phytochemical profiles of medicinal plants.
Conducted a comprehensive literature review covering studies from 2015 to 2025.
Prioritized experimental studies examining climate-related biochemical modulation.
Included multi-omic approaches and metabolomic analyses.
Elevated CO₂ levels increased carbon flow towards phenolic and flavonoid metabolites.
Heat stress and drought significantly enhanced terpenoid and alkaloid biosynthesis via transcription factor activation.
Increased UV-B exposure consistently promoted flavonoid accumulation as a photoprotective mechanism.

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Review evaluates climate effects on plant metabolites in medicinal species, suggesting impacts on therapeutic quality.

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Ufuk Kuşkun (2026) studied this question.

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