Case report highlights the difficulty of diagnosing embryonal carcinoma with signet-ring features in a young girl, suggesting caution in cytology interpretation.
The morphology of a signet-ring can be imparted by a number of benign and malignant neoplasms. This poses a significant diagnostic pitfall in such cases, owing to deceptive cell cytology, scattered, scant cells, and the accumulation of large cytoplasmic mucin vacuoles, giving the characteristic 'signet ring cell appearance'. Herein, we present a case of embryonal carcinoma in the retroperitoneal region in a 13-year-old girl. Fine needle aspiration cytology can be misleading due to the presence of signet-ring-like cells. We present a rare case of embryonal carcinoma with signet-ring differentiation and its cytohistological correlation.
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Sharma et al. (2026) studied this question.
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