Therapeutic leukapheresis with severe pertussis: evaluating efficacy, feasibility, and safety.

May 2, 2026

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This research aims to assess the efficacy, safety, and feasibility of therapeutic leukapheresis versus exchange transfusion in children with severe pertussis.
Retrospective analysis of children ≤4 years hospitalized with severe pertussis from Jan 1 to May 31, 2024.
Patients were divided into three groups: Primary TL (4 patients), ET Only (4 patients), and Salvage TL (6 patients).
Comparison of clinical characteristics, hematological responses, and resource utilization.
Primary TL reduced median WBC counts from 50.6 to 24.8×10^9/L, ET only from 43.0 to 25.6×10^9/L.
Post-treatment platelet counts were comparable between Primary TL and ET groups (p=1.000).
Primary TL showed 0% mortality, contrasting with a 33.3% mortality in Salvage TL cases.

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Retrospective analysis evaluates therapeutic leukapheresis effectiveness in severe pertussis, highlighting its safety and resource-saving potential.

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Gao et al. (2026) studied this question.

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