Dual Quantification of Skeletal Muscle Perfusion and Metabolism in a Porcine Model of Peripheral Artery Disease Using Multiparametric ¹⁸F-FDG PET Imaging.

May 1, 2026

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Key Points

This study aims to investigate alterations in skeletal muscle perfusion and metabolism due to peripheral artery disease (PAD) in a porcine model.
Utilized multiparametric 18F-FDG PET imaging in a porcine model of PAD.
Measured calf muscle perfusion and glucose metabolic rate at rest following femoral artery ligation.
Compared microvascular density between ischemic and control hindlimbs after two weeks.
Calf muscle perfusion significantly reduced post-arterial occlusion, recovering to control levels after two weeks.
The metabolic rate of glucose (MRGlu) was also significantly reduced and returned to normal levels.
Increased calf muscle capillary density was observed two weeks post-occlusion.

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Evaluates muscle perfusion and metabolism in a porcine model of peripheral artery disease, suggesting new treatment monitoring approaches.

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Chou et al. (2026) studied this question.

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